Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma

被引：106

作者：

Bang, YJ ^{[1
]}

Kwon, JH ^{[1
]}

Kang, SH ^{[1
]}

Kim, JW ^{[1
]}

Yang, YC ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Canc Res Ctr, Seoul 151, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 250卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.9256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitogen-activated protein kinase (MAPK) has been known to play a critical role in the regulation of the carcinogenesis in human cancers. In an effort to understand the functional role of the MAPK in the carcinogenesis of human gastric tissues, we examined the changes of MAPK levels in human gastric adenocarcinoma, We found that increased MAPK activity was accompanied by overexpression of mitogen-activated protein kinase phosphatase-l (MKP-1), suggesting that signaling pathways leading to the activation of MAPK and the induction of MKP-1 expression are associated with carcinogenesis of human gastric adenocarcinoma, (C) 1998 Academic Press.

引用

页码：43 / 47

页数：5

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