Studies on MCM-41 mesoporous silica for drug delivery:: Effect of particle morphology and amine functionalization

被引：388

作者：

Manzano, M. ^{[1
]}

Aina, V. ^{[1
]}

Arean, C. O. ^{[2
]}

Balas, F. ^{[1
]}

Cauda, V. ^{[1
]}

Colilla, M. ^{[1
]}

Delgado, M. R. ^{[2
]}

Vallet-Regi, M. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain

[2] Univ Islas Baleares, Dept Quim, Palma de Mallorca 07122, Spain

来源：

CHEMICAL ENGINEERING JOURNAL | 2008年 / 137卷 / 01期

关键词：

silica-based mesoporous materials; drug delivery systems;

D O I：

10.1016/j.cej.2007.07.078

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Mesoporous MCM-41 silica functionalized by 3-aminopropyltriethoxysilane grafting was studied as a potential carrier for controlled drug release, using ibuprofen as a test drug. For comparison, non-functionahzed MCM-41 was also investigated. For the purpose of testing the effect of carrier morphology on drug delivery rate, MCM-41 was prepared in the form of both, a powder consisting of irregularly shaped (and sized) particles and monodispersed spheres (490 to 770 nm in diameter). Amine-functionalized MCM-41 micro-spheres were found to show a significantly slower drug release rate than irregularly shaped powders, which should facilitate drug delivery control over a longer time period. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：30 / 37

页数：8

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