Discovering functional relationships: biochemistry versus genetics

被引：21

作者：

Wong, SL ^{[1
]}

Zhang, LV ^{[1
]}

Roth, FP ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 08期

关键词：

D O I：

10.1016/j.tig.2005.06.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Biochemists and geneticists, represented by Doug and Bill in classic essays, have long debated the merits of their methods. We revisited this issue using genomic data from the budding yeast, Saccharomyces cerevisiae, and found that genetic interactions outperformed protein interactions in predicting functional relationships between genes. However, when combined, these interaction types yielded superior performance, convincing Doug and Bill to call a truce.

引用

页码：424 / 427

页数：4

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