Fungal lethality, binding, and cytotoxicity of syringomycin-E

被引：25

作者：

De Lucca, AJ

Jacks, TJ

Takemoto, J

Vinyard, B

Peter, J

Navarro, E

Walsh, TJ

机构：

[1] USDA ARS, So Reg Res Ctr, New Orleans, LA 70124 USA

[2] Utah State Univ, Dept Biol, Logan, UT 84322 USA

[3] USDA ARS, Biometr Consulting Serv, Beltsville, MD USA

[4] NCI, Immunocompromised Host Sect, Pediat Branch, NIH, Bethesda, MD 20892 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1128/AAC.43.2.371

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 mu g/ml. SE complexed with the following fungal wall constituents tin order of binding): beta-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.

引用

页码：371 / 373

页数：3

共 24 条

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