Distinguishing subregions of the human MT plus complex using visual fields and pursuit eye movements

被引:225
作者
Dukelow, SP
DeSouza, JFX
Culham, JC
van den Berg, AV
Menon, RS
Vilis, T
机构
[1] Univ Western Ontario, Dept Physiol, CIHR Grp Act & Percept, London, ON N6A 5C1, Canada
[2] Univ Western Ontario, Dept Psychol, London, ON N6A 5C2, Canada
[3] Univ Western Ontario, Siebens Drake Res Inst, Grad Program Neurosci, London, ON N6A 2V4, Canada
[4] John P Robarts Res Inst, Adv Imaging Labs, London, ON N6A 5K8, Canada
[5] Erasmus Univ, Dept Physiol, NL-3000 DR Rotterdam, Netherlands
关键词
D O I
10.1152/jn.2001.86.4.1991
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In humans, functional imaging studies have demonstrated a homologue of the macaque motion complex, MT+ [suggested to contain both middle temporal (MT) and medial superior temporal (MST)], in the ascending limb of the inferior temporal sulcus. In the macaque monkey, motion-sensitive areas MT and MST are adjacent in the superior temporal sulcus. Electrophysiological research has demonstrated that while MT receptive fields primarily encode the contralateral visual field, MST dorsal (MSTd) receptive fields extend well into the ipsilateral visual field. Additionally, macaque MST has been shown to receive extraretinal smooth-pursuit eye-movement signals, whereas MT does not. We used functional magnetic resonance imaging (fMRI) and the neural properties that had been observed in monkeys to distinguish putative human areas MT from MST. Optic flow stimuli placed in the full field, or contralateral field only, produced a large cluster of functional activation in our subjects consistent with previous reports of human area MT+. Ipsilateral optic flow stimuli limited to the peripheral retina produced activation only in an anterior subsection of the MT+ complex, likely corresponding to putative MSTd. During visual pursuit of a single target, a large portion of the MT+ complex was activated. However, during nonvisual pursuit, only the anterolateral portion of the MT+ complex was activated. This subsection of the MT+ cluster could correspond to putative MSTl (lateral). In summary, we observed three distinct subregions of the human MT+ complex that were arranged in a manner similar to that seen in the monkey.
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页码:1991 / 2000
页数:10
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