A cyclopropanol approach to the synthesis of the C13-C21 fragment of epothilones from diethyl (S)-malate

被引：24

作者：

Bekish, AV ^{[1
]}

Isakov, VE ^{[1
]}

Kulinkovich, OG ^{[1
]}

机构：

[1] Belarusian State Univ, Dept Organ Chem, Minsk 220050, BELARUS

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 41期

关键词：

(S)-malic acid; cyclopropanols; allyl halides; epothilones;

D O I：

10.1016/j.tetlet.2005.08.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient new approach to the synthesis of the C13-C21 epothilone fragment using the cyclopropanation of the ethoxycarbonyl groups in O-THP protected diethyl (S)-malate with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide followed by site-selective cyclopropane cleavage as the key steps has been performed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6979 / 6981

页数：3

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