J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs

被引：16

作者：

Iwasawa, Y

Shibata, J

Mitsuya, M

Masaki, H

Hayashi, M

Kanno, T

Sawasaki, Y

Hisaka, A

Kamei, T

Tomimoto, K

机构：

[1] Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Tsukuba 300-33

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/0960-894X(96)00033-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

J-104,123, a potent inhibitor of squalene synthase having monocarboxylic acid structure, was discovered by chemical modification of J-104,118. An oral dose of J-104,123 lowered serum cholesterol levels in dogs. J-104,123 was synthesized stereoselectively from methyl (R)-3-hydroxybutyrate.

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收藏

页码：463 / 466

页数：4

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