Nongenomic, estrogen receptor-mediated activation of endothelial nitric oxide synthase - How does it work? What does it mean?

被引：127

作者：

Mendelsohn, ME ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, New England Med Ctr, Mol Cardiol Res Inst, Boston, MA 02111 USA

来源：

CIRCULATION RESEARCH | 2000年 / 87卷 / 11期

关键词：

estrogen; receptor; endothelium; nitric oxide; caveolae;

D O I：

10.1161/01.RES.87.11.956

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The administration of estrogens in animals tends to inhibit the development of atherosclerosis... [Therefore], attempts are being made in human males to prevent further progress of the disease in cases of angina or previous coronary thrombosis by long-range estrogen therapy. This work is in its infancy. It is hoped that, with further research, compounds might be found that eliminate the undesirable action of such hormones and yet retain its beneficial effects on arteries (Samuel A. Levine, 1958).

引用

页码：956 / 960

页数：5

共 37 条

[1]

CaulinGlaser T, 1997, CIRC RES, V81, P885

[2] Effects of 17 beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression [J].

CaulinGlaser, T ;

Watson, CA ;

Pardi, R ;

Bender, JR .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (01) :36-42

[3] Estrogen receptor α and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae [J].

Chambliss, KL ;

Yuhanna, IS ;

Mineo, C ;

Liu, PS ;

German, Z ;

Sherman, TS ;

Mendelsohn, ME ;

Anderson, RGW ;

Shaul, PW .

CIRCULATION RESEARCH, 2000, 87 (11) :E44-E52

[4] Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen [J].

Chen, Z ;

Yuhanna, IS ;

Galcheva-Gargova, Z ;

Karas, RH ;

Mendelsohn, RE ;

Shaul, PW .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (03) :401-406

[5] Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation [J].

Dimmeler, S ;

Fleming, I ;

Fisslthaler, B ;

Hermann, C ;

Busse, R ;

Zeiher, AM .

NATURE, 1999, 399 (6736) :601-605

[6] Rapid activation of MAP kinase by estrogen in the bone cell line [J].

Endoh, H ;

Sasaki, H ;

Maruyama, K ;

Takeyama, K ;

Waga, I ;

Shimizu, T ;

Kato, S ;

Kawashima, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (01) :99-102

[7] Identification of a new isoform of the human estrogen receptor-alpha (hER-α) that is encoded by distinct transcripts and that is able to repress hER-α activation function 1 [J].

Flouriot, G ;

Brand, H ;

Denger, S ;

Metivier, R ;

Kos, M ;

Reid, G ;

Sonntag-Buck, V ;

Gannon, F .

EMBO JOURNAL, 2000, 19 (17) :4688-4700

[8] Regulation of endothelium-derived nitric oxide production by the protein kinase Akt [J].

Fulton, D ;

Gratton, JP ;

McCabe, TJ ;

Fontana, J ;

Fujio, Y ;

Walsh, K ;

Franke, TF ;

Papapetropoulos, A ;

Sessa, WC .

NATURE, 1999, 399 (6736) :597-601

[9] Dynamic activation of endothelial nitric oxide synthase by Hsp90 [J].

García-Cardeña, G ;

Fan, R ;

Shah, V ;

Sorrentino, R ;

Cirino, G ;

Papapetropoulos, A ;

Sessa, WC .

NATURE, 1998, 392 (6678) :821-824

[10] HORMONE-THERAPY TO PREVENT DISEASE AND PROLONG LIFE IN POSTMENOPAUSAL WOMEN [J].

GRADY, D ;

RUBIN, SM ;

PETITTI, DB ;

FOX, CS ;

BLACK, D ;

ETTINGER, B ;

ERNSTER, VL ;

CUMMINGS, SR .

ANNALS OF INTERNAL MEDICINE, 1992, 117 (12) :1016-1037

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