B-, T-, and NK-cell lineage involvement in JAK2V617F-positive patients with idiopathic myelofibrosis

被引：22

作者：

Bogani, Costanza ^{[1
]}

Guglielmelli, Paola ^{[1
]}

Antonioli, Elisabetta ^{[1
]}

Pancrazzi, Alessandro ^{[1
]}

Bosi, Alberto ^{[1
]}

Vannucchi, Alessandro Maria ^{[1
]}

机构：

[1] Univ Florence, Dept Hematol, I-50134 Florence, Italy

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 02期

关键词：

JAK2; idiopathic myelofibrosis; myeloproliferative disease; stem cells;

D O I：

10.3324/haematol.10527

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An acquired JAK2(V617F) mutation has been found in myeloid cells from most patients with chronic idiopathic myelofibrosis (IM), but whether it occurs in a common myelo-lymphoid, rather than a myeloid-restricted, progenitor cell is still debated. Using a sensitive ARMS assay for the quantitative assessment of JAK2(V617F) cDNA, we detected the mutation in purified B, T and NK cells from about half of 12 patients studied. These results indicate that involvement of the lymphoid lineage in IM may be more frequent than previously supposed.

引用

页码：258 / 259

页数：2

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