Small-molecule-based strategies for controlling gene expression

被引：91

作者：

Denison, C

Kodadek, T

机构：

[1] Univ Texas, SW Med Ctr, Ctr Biomed Invent, Dept Internal Med, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Ctr Biomed Invent, Dept Biochem, Dallas, TX 75235 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1074-5521(98)90167-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A central goal in chemical biology is to gain control over biological pathways using small molecules, and the mRNA-synthesizing machinery is a particularly important target. New advances in our understanding of transcriptional regulation suggests strategies to manipulate these pathways using small molecules.

引用

页码：R129 / R145

页数：17

共 110 条

[1] Yeast TAF(II)90 is required for cell-cycle progression through G(2)/M but not for general transcription activation
Apone, LM
Virbasius, CMA
Reese, JC
Green, MR
[J]. GENES & DEVELOPMENT, 1996, 10 (18) : 2368 - 2380
[2] CONTACT WITH A COMPONENT OF THE POLYMERASE-II HOLOENZYME SUFFICES FOR GENE ACTIVATION
BARBERIS, A
PEARLBERG, J
SIMKOVICH, N
FARRELL, S
REINAGEL, P
BAMDAD, C
SIGAL, G
PTASHNE, M
[J]. CELL, 1995, 81 (03) : 359 - 368
[3] GENETIC ISOLATION OF ADA2 - A POTENTIAL TRANSCRIPTIONAL ADAPTER REQUIRED FOR FUNCTION OF CERTAIN ACIDIC ACTIVATION DOMAINS
BERGER, SL
PINA, B
SILVERMAN, N
MARCUS, GA
AGAPITE, J
REGIER, JL
TRIEZENBERG, SJ
GUARENTE, L
[J]. CELL, 1992, 70 (02) : 251 - 265
[4] Mediator of transcriptional regulation
Bjorklund, S
Kim, YJ
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1996, 21 (09) : 335 - 337
[5] Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale
Borchardt, A
Liberles, SD
Biggar, SR
Crabtree, GR
Schreiber, SL
[J]. CHEMISTRY & BIOLOGY, 1997, 4 (12): : 961 - 968
[6] Combinatorial chemistry
Borman, S
[J]. CHEMICAL & ENGINEERING NEWS, 1997, 75 (08) : 43 - &
[7] Retinoblastoma protein recruits histone deacetylase to repress transcription
Brehm, A
Miska, EA
McCance, DJ
Reid, JL
Bannister, AJ
Kouzarides, T
[J]. NATURE, 1998, 391 (6667) : 597 - 601
[8] Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch
Bremer, RE
Baird, EE
Dervan, PB
[J]. CHEMISTRY & BIOLOGY, 1998, 5 (03): : 119 - 133
[9] A EUKARYOTIC TRANSCRIPTIONAL ACTIVATOR BEARING THE DNA SPECIFICITY OF A PROKARYOTIC REPRESSOR
BRENT, R
PTASHNE, M
[J]. CELL, 1985, 43 (03) : 729 - 736
[10] Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation
Brownell, JE
Allis, CD
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (02) : 176 - 184

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