Small-molecule-based strategies for controlling gene expression

被引：91

作者：

Denison, C

Kodadek, T

机构：

[1] Univ Texas, SW Med Ctr, Ctr Biomed Invent, Dept Internal Med, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Ctr Biomed Invent, Dept Biochem, Dallas, TX 75235 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1074-5521(98)90167-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A central goal in chemical biology is to gain control over biological pathways using small molecules, and the mRNA-synthesizing machinery is a particularly important target. New advances in our understanding of transcriptional regulation suggests strategies to manipulate these pathways using small molecules.

引用

页码：R129 / R145

页数：17

共 110 条

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