Recent progress in the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus

被引：83

作者：

Hayashi, M ^{[1
]}

Nakayama, Y ^{[1
]}

Unemoto, T ^{[1
]}

机构：

[1] Chiba Univ, Fac Pharmaceut Sci, Lab Membrane Biochem, Inage Ku, Chiba 2638522, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2001年 / 1505卷 / 01期

关键词：

Na+ pump; NADH-quinone reductase; respiratory chain; flavin cofactor; marine bacterium; Vibrio alginolyticus;

D O I：

10.1016/S0005-2728(00)00275-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The respiratory chain of Cram-negative marine and halophilic bacteria has a Na+-dependent NADH-quinone reductase that functions as a primary Na+ pump. The Na+-translocating NADH-quinone reductase (NQR) from the marine Vibrio alginolyticus is composed of six structural genes (nqrA to nqrF). The NqrF subunit has non-covalently bound FAD. There are conflicting results on the existence of other flavin cofactors. Recent studies revealed that the NqrB and NqrC subunits have a covalently bound flavin, possibly FMN, which is attached to a specified threonine residue. A novel antibiotic, korormicin, was found to specifically inhibit the NQR complex. From the homology search of the nqr operon, it was found that the Na+-pumping NQR complex is widely distributed among Gram-negative pathogenic bacteria. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：37 / 44

页数：8

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