Stereoselective preparation of functionalized tertiary P-chiral phosphine oxides by nucleophilic addition of lithiated tert-butylphenylphosphine oxide to carbonyl compounds.

被引：50

作者：

Haynes, RK

Lam, WWL

Yeung, LL

机构：

[1] Department of Chemistry, Hong Kong Univ. of Sci. and Technol., Kowloon, Clear Water Bay Road

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 27期

关键词：

D O I：

10.1016/0040-4039(96)00952-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic carbonyl and conjugate addition reactions of configurationally stable lithiated P-chiral tert-butylphenylphosphine oxide with aldehydes and alpha,beta-unsaturated carbonyl compounds occur in good yields with diastereoselectivities ranging from 33 to greater than or equal to 98%. Copyright (C) 1996 Elsevier Science Ltd

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页码：4729 / 4732

页数：4

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