Synthesis and biological activity of new cycloalkylthiophene-Schiff bases and their Cr(III) and Zn(II) complexes

被引：39

作者：

Altundas, Aliye ^{[1
]}

Sari, Nursen ^{[1
]}

Colak, Naki ^{[2
]}

Ogutcu, Hatice ^{[3
]}

机构：

[1] Gazi Univ, Fac Sci & Arts, Dept Chem, TR-06500 Ankara, Turkey

[2] Hitit Univ, Fac Sci & Arts, Dept Chem, Corum, Turkey

[3] Refik Saydam Hyg Ctr, TR-06100 Ankara, Turkey

来源：

MEDICINAL CHEMISTRY RESEARCH | 2010年 / 19卷 / 06期

关键词：

Sulfur; Gewald methods; Cycloalkylthiophenes; Schiff bases; Antimicrobial activity; Drug; ANTIMICROBIAL ACTIVITY; AMINO-ACID; METAL; 2-AMINOTHIOPHENES; CONDUCTIVITY; DERIVATIVES; COPPER(II); CO(II);

D O I：

10.1007/s00044-009-9214-8

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A series of some novel Ethyl 2-((1-hydroxynaphthalen-2-yl)methyleneamino)-5,6-dihydro-4H-cyclopenta[b]thiopehene-3-carboxylate, Ethyl 2-((1-hydroxynaphthalen-2-yl)methyleneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, Ethyl 2-((1-hydroxynaphtalen-2-yl)methyleneamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate and their Cr(III) and Zn(II) complexes have been synthesized. All of these substances have been examined for antibacterial activity against pathogenic strains Listeria monocytogenes 4b (ATCC-19115), Staphylococcus aureus (ATCC25923), Proteus OX2 Wrah (ETS.40-A-4), Escherichia coli (ATCC-1280), Salmonella typhi H (NCTC-901.8394), Pseudomonas putida sp., Brucella abortus (A.99, UK-1995) RSKK-03026. Sh. boydii type 11 (Pasteur51.6), Sh. boydii type 16 (cHe 67.11), Sh. boydii type 6 (RSKK-96043), and antifungal activity against Candida albicans (Y-1200-NIH, Tokyo). Some of the compounds exhibited activity comparable to ampicillin ofloxacin, nystatin, kanamycin, sulphamethoxazol, amoxycillin, and chloroamphenicol. Most of the studied compounds were found effective against bacteria studied and yeast.

引用

页码：576 / 588

页数：13

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