The link between glutamate and migraine

被引：79

作者：

Ramadan, NM ^{[1
]}

机构：

[1] Finch Univ Hlth Sci Chicago Med Sch, Dept Neurol, N Chicago, IL 60064 USA

来源：

CNS SPECTRUMS | 2003年 / 8卷 / 06期

关键词：

D O I：

10.1017/S1092852900018757

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Migraine pain-relay centers, including the trigeminal ganglion, trigeminal nucleas caudalis, and thalamus, contain glutamate-positive neurons, and glutamate activates the trigeminal nucleus caudalis. Glutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. Glatamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. These preclinical and clinical observations argue for a strong link between migraine and the glutamatergic system, a link that is important to further characterize in an effort to better understand migraine mechanisms and deliver effective therapies.

引用

页码：446 / 449

页数：4

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