Immunological basis for reactivation of tuberculosis in mice

被引:52
作者
Turner, J [1 ]
Gonzalez-Juarrero, M
Saunders, BM
Brooks, JV
Marietta, P
Ellis, DL
Frank, AA
Cooper, AM
机构
[1] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA
[2] Colorado State Univ, Dept Pathol, Ft Collins, CO 80523 USA
关键词
D O I
10.1128/IAI.69.5.3264-3270.2001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this study different inbred strains of mice appeared to control and contain a low dose aerosol infection with Mycobacterium tuberculosis in a similar manner, giving rise tu a chronic state of disease. Thereafter, however, certain strains gradually began to show evidence of regrowth of the infection, whereas others consistently did not. Using C57BL/6 mice as an example of a resistant strain and CBA/J mice as an example of a strain susceptible to bacterial growth, we found that these animals revealed distinct differences in the cellular makeup of lung granulomas. The CBA/J mice exhibited a generally poor lymphocyte response within the lungs and vastly increased degenerative pathology at a time associated with regrowth of the infection. As a possible explanation for these events, it was then observed that the CBA/J mouse strain was also less able to upregulate adhesion molecules, including CD11a and CD54, on circulating lymphocytes. These results therefore suggest that a failure to control a chronic infection with M. tuberculosis may reflect an inability to localize antigen-specific lymphocytes within the lung.
引用
收藏
页码:3264 / 3270
页数:7
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