Inflammation at the blood-brain barrier: The role of liver X receptors

被引：21

作者：

de Wit, N. M. ^{[1
]}

Vanmol, J. ^{[2
]}

Kamermans, A. ^{[1
]}

Hendriks, J. J. A. ^{[2
]}

de Vries, H. E. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Neurosci Campus Amsterdam, POB 7057, NL-1007 MB Amsterdam, Netherlands

[2] Hasselt Univ, Transnat Univ Limburg, Sch Life Sci, Biomed Res Inst, Diepenbeek, Belgium

来源：

NEUROBIOLOGY OF DISEASE | 2017年 / 107卷

关键词：

Liver X receptor; Blood-brain barrier; Neuroinflammation; Neurodegenerative disease; Tight junction; CENTRAL-NERVOUS-SYSTEM; VASCULAR ENDOTHELIAL-CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ADHESION MOLECULE-1 EXPRESSION; OXIDE SYNTHASE EXPRESSION; FACTOR-KAPPA-B; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS; NITRIC-OXIDE; MOUSE MODEL;

D O I：

10.1016/j.nbd.2016.09.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases. (C) 2016 Elsevier Inc. All rights reserved.

引用

收藏

页码：57 / 65

页数：9

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