High prevalence of TT virus-related DNA (90%) and diverse viral genotypes in Norwegian blood donors

被引：35

作者：

Huang, LY ^{[1
]}

Jonassen, TO ^{[1
]}

Hungnes, O ^{[1
]}

Grinde, B ^{[1
]}

机构：

[1] Natl Inst Publ Hlth, Dept Virol, N-0403 Oslo, Norway

来源：

JOURNAL OF MEDICAL VIROLOGY | 2001年 / 64卷 / 03期

关键词：

TT virus; prevalence; PCR; sequence analysis; TLMV;

D O I：

10.1002/jmv.1062

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Early estimates of the prevalence of TTV viremia in healthy adults of developed countries were in the order of 1-10 %, while similar estimates in Third World countries were considerably higher. Using three different PCRs, TTV-related DNA was detected in serum from 180 out of the 201 Norwegian blood donors tested, indicating that these viruses are almost universally present in adults. Sequence analysis revealed heterogeneity similar to what is found world-wide. The data suggest that the previous discrepancy in prevalences might be related to a lower serum concentration of virus in developed countries. The high prevalence adds evidence to the benign nature of the virus. (C) 2001 Wiley-Liss, Inc.

引用

页码：381 / 386

页数：6

共 77 条

[1] TT virus sequence heterogeneity in vivo:: evidence for co-infection with multiple genetic types [J].