The tight junction: Morphology to molecules

被引:208
作者
Stevenson, BR [1 ]
Keon, BH
机构
[1] Univ Alberta, Dept Anat & Cell Biol, Edmonton, AB T6G 2H7, Canada
[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
关键词
epithelium; intercellular junctions; MAGUK protein family; paracellular pathway; tumor suppress;
D O I
10.1146/annurev.cellbio.14.1.89
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The tight junction forms a regulated barrier in the paracellular pathway between epithelial and endothelial cells. This intercellular junction also demarcates the compositionally distinct apical and basolateral membranes. While the existence of a paracellular barrier in epithelia was hypothesized by physiologists over a century ago, the molecular characterization of the tight junction is a relatively new and rapidly expanding area of research. It is now recognized that the tight junction is comprised of at least nine peripheral and one integral membrane proteins. This complex includes members of a protein family related to tumor suppression and signal transduction, a rab protein, and a Ras target protein. The characteristics of, interactions between, and potential physiological roles of these proteins at the tight junction are discussed.
引用
收藏
页码:89 / 109
页数:21
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