Wnt signaling: multiple functions in neural development

被引：156

作者：

Ille, F ^{[1
]}

Sommer, L ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Dept Biol, Inst Cell Biol, CH-8093 Zurich, Switzerland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 10期

关键词：

Wnt signaling; beta-catenin; frizzled receptor; proliferation; apoptosis; stem cell maintenance; differentiation; lineage decision; axon guidance; neurite outgrowth;

D O I：

10.1007/s00018-005-4552-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt signaling has proven to be essential for neural development at various stages and across species. Wnts are involved in morphogenesis and patterning, and their proliferation-promoting role is a key function in stem cell maintenance and the expansion of progenitor pools. Moreover, Wnt signaling is involved in differentiation processes and lineage decision events during both central and peripheral nervous system development. Additionally, several reports point to a role of Wnt signaling in axon guidance and neurite outgrowth. This article reviews and consolidates the existing evidence for the functions of Wnt signaling in neural development.

引用

页码：1100 / 1108

页数：9

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