Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

被引：65

作者：

da Silva Oliveira, Kelly Cristina ^{[1
]}

Thomaz Araujo, Taissa Maira ^{[1
]}

Albuquerque, Camila Inagaki ^{[1
]}

Barata, Gabriela Alcantara ^{[1
]}

Gigek, Carolina Oliveira ^{[2
]}

Leal, Mariana Ferreira ^{[2
]}

Wisnieski, Fernanda ^{[2
]}

Rodrigues Mello Junior, Fernando Augusto ^{[1
]}

Khayat, Andre Salim ^{[1
]}

de Assumpcao, Paulo Pimentel ^{[1
]}

Rodriguez Burbano, Rommel Mario ^{[3
]}

Smith, Marilia Cardoso ^{[2
]}

Calcagno, Danielle Queiroz ^{[1
]}

机构：

[1] Fed Univ Para, Hosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, 2 Piso UNACON,Av Mundurucus, BR-66073000 Belem, PA, Brazil

[2] Univ Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04021001 Sao Paulo, Brazil

[3] Fed Univ Para, Lab Citogenet Humana, Inst Ciencias Biol, BR-66073000 Belem, PA, Brazil

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 35期

关键词：

Gastric cancer; Epigenetic; Diagnostic biomarkers; miRNAs; Prognostic biomarkers; MESSENGER-RNA EXPRESSION; CELL-PROLIFERATION; MULTIDRUG-RESISTANCE; UP-REGULATION; BINDING-SITE; DIFFERENTIAL EXPRESSION; CIRCULATING MICRORNAS; ALTERS SUSCEPTIBILITY; EPIGENETIC REGULATION; HISTONE DEACETYLASE;

D O I：

10.3748/wjg.v22.i35.7951

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.

引用

页码：7951 / 7962

页数：12

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