Peptidomics of the locust corpora allata: identification of novel pyrokinins (-FXPRLamides)

被引：33

作者：

Clynen, E ^{[1
]}

Baggerman, G ^{[1
]}

Huybrechts, J ^{[1
]}

Vanden Bosch, L ^{[1
]}

De Loof, A ^{[1
]}

Schoofs, L ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Dev Physiol Genom & Proteom, B-3000 Louvain, Belgium

来源：

PEPTIDES | 2003年 / 24卷 / 10期

关键词：

allatostatins; endocrinology; juvenile hormone; Locusta migratoria; MALDI-TOF; mass spectrometry; neuropeptides; peptidome; pyrokinins; Schistocerca gregaria; CENTRAL-NERVOUS-SYSTEM; SCHISTOCERCA-GREGARIA; DESERT LOCUST; MANDUCA-SEXTA; PHEROMONE BIOSYNTHESIS; IMMUNOREACTIVE NEURONS; FUNCTIONAL DIVERSITY; TOBACCO HORNWORM; NEUROPEPTIDE; MIGRATORIA;

D O I：

10.1016/j.peptides.2003.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The peptidomes of the corpora allata of Locusta migratoria and Schistocerca gregaria were investigated by both matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and nanoscale liquid chromatography quadrupole time-of-flight tandem mass spectrometry (nanoLC-Q-TOF MSMS). The pyrokinin (-FXPRLamide) family seems to be predominant. In addition to the known pyrokinins, we de novo sequenced four pyrokinins in L migratoria and five in S. gregaria. In addition, one pyrokinin-like peptide (-PRLamide) was identified in S. gregaria. Besides the -(FX)PRLamides, FLRFamide-l, the allatostatins (A family) and numerous as yet unidentified peptides are also present in the corpora allata. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1493 / 1500

页数：8

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