Asymmetric synthesis of 2-substituted piperidines using a multi-component coupling reaction:: rapid assembly of (S)-coniine from (S)-1-(1-phenylethyl)-2-methyleneaziridine

被引：45

作者：

Hayes, JF

Shipman, M ^{[1
]}

Twin, H

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

[2] GlaxoSmithKline, Tonbridge TN11 9AN, Kent, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 18期

关键词：

D O I：

10.1039/b106260n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(S)-Coniine is made using a reaction which assembles the piperidine ring by the sequential formation of four new chemical bonds and installs the C-2 stereogenic centre with high levels of diastereocontrol (90% de).

引用

页码：1784 / 1785

页数：2

共 24 条

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