External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis

被引:54
作者
Andersen, PM
Grönberg, H
Franzen, L
Funegård, U
机构
[1] Umea Univ, Dept Clin Neurosci, Umea, Sweden
[2] Umea Univ, Dept Radiat Sci, Umea, Sweden
[3] Umea Univ, Dept Oncol, Umea, Sweden
[4] Umea Univ, Dept Odontol, Umea, Sweden
关键词
ALS; motor neurone disease; drooling; quality of life; terminal care;
D O I
10.1016/S0022-510X(01)00631-1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The parotid glands and part of the submandibular glands were irradiated in 18 amyotrophic lateral sclerosis patients with very advanced disease and severe drooling problems. In a prospective study, a single dosage of 7.0-7.5 Gy was administered bilateral to the larger part of the parotid glands and the posterior parts of the submandibular glands. Salivary secretion rate was assayed before and after radiotherapy. Sixteen out of eighteen patients reported satisfactory to good reduction in drooling lasting up to 4-6 months, 1/18 developed xerostomia and needed saliva substitutes, and 1/18 reported no effect. Caregivers reported positive effect in all patients. The procedure was well tolerated with few side effects. Low dosage external radiotherapy of the salivary glands is effective in reducing drooling satisfactorily in ALS patients, especially in well-hydrated patients. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:111 / 114
页数:4
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