Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis

被引：145

作者：

Giess, R

Naumann, M

Werner, E

Riemann, R

Beck, M

Puls, I

Reiners, C

Toyka, KV

机构：

[1] Univ Wurzburg, Dept Neurol, D-97080 Wuerzburg, Germany

[2] Univ Wurzburg, Dept Nucl Med, D-97080 Wuerzburg, Germany

[3] Univ Wurzburg, Dept Otorhinolaryngol, D-97080 Wuerzburg, Germany

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2000年 / 69卷 / 01期

关键词：

ALS; sialorrhoea; salivary glands; botulinum toxin A;

D O I：

10.1136/jnnp.69.1.121

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sialorrhoea is a socially disabling problem in bulbar amyotrophic lateral sclerosis (ALS). Botulinum toxin A (BoNT/A) was injected into the salivary glands in five patients with bulbar ALS and sialorrhoea. The effect of BoNT/A was measured by the number of paper handkerchiefs used each day and by salivary gland scintigraphy. BoNT/A ameliorated sialorrhoea and quality of life without major adverse effects. BoNT/A may be a relatively safe and effective treatment for sialorrhoea in selected patients.

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页码：121 / 123

页数：3

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