Synthesis of DNA-(3′)-PNA chimeras with conformationally restricted linkers based on 4-hydroxyproline

被引：17

作者：

Verheijen, JC ^{[1
]}

van Roon, AMM ^{[1
]}

van der Laan, AC ^{[1
]}

van der Marel, GA ^{[1
]}

van Boom, JH ^{[1
]}

机构：

[1] Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 03期

关键词：

D O I：

10.1080/15257779908043093

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and evaluation of DNA-(3')-PNA chimeras containing rigid linkers based on (R/S)-4-hydroxy-D/L-proline are described. It is shown that installment of the trans-L-linker using the tetrabutylammonium salt of (R)-4-(4,4'-dimethoxytrityloxy)-N-(thymin-1-yl)acetyl-L-proline (2) leads to a DNA-(3')-PNA chimera which hybridizes efficiently with complementary RNA.

引用

页码：493 / 508

页数：16

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