Nucleoproteins and nucleocapsids of negative-strand RNA viruses

被引：191

作者：

Ruigrok, Rob W. H. ^{[1
]}

Crepin, Thibaut ^{[1
]}

Kolakofsky, Dan ^{[2
]}

机构：

[1] UJF EMBL CNRS, Unit Virus Host Cell Interact, UMI 3265, F-38042 Grenoble 9, France

[2] Univ Geneva, Dept Microbiol & Mol Med, Sch Med, CMU, CH-1211 Geneva, Switzerland

来源：

CURRENT OPINION IN MICROBIOLOGY | 2011年 / 14卷 / 04期

关键词：

VESICULAR STOMATITIS-VIRUS; CRYSTAL-STRUCTURE; INFLUENZA-VIRUS; POLYMERASE; COMPLEX; BINDING; PHOSPHOPROTEIN; REPLICATION; MECHANISM; REQUIRES;

D O I：

10.1016/j.mib.2011.07.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A hallmark of negative-strand RNA viruses (NSVs) is that their genomes never exist as free RNA, but instead are always assembled with many copies of a single nucleoprotein (N) to form highly stable nucleocapsids. Moreover, viral genomes are the only RNAs in infected cells that are assembled with N. The mechanism by which this specific association occurs, for both the segmented (s) and non-segmented (ns) viruses, has recently become clearer due to our expanding knowledge of N protein and nucleocapsid structures.

引用

页码：504 / 510

页数：7

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