Arf family GTP loading is activated by, and generates, positive membrane curvature

被引：77

作者：

Lundmark, Richard ^{[1
]}

Doherty, Gary J. ^{[1
]}

Vallis, Yvonne ^{[1
]}

Peter, Brian J. ^{[1
]}

Mcmahon, Harvey T. ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

来源：

BIOCHEMICAL JOURNAL | 2008年 / 414卷 / 189-194期

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

ADP-ribosylation factor family (Arf family); amphipathic helix; clathrin-mediated endocytosis; coatamer protein (COP); membrane curvature sensing and generation; small G-protein;

D O I：

10.1042/BJ20081237

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curvature. Arf I and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix.

引用

页码：189 / 194

页数：6

共 27 条

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