Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

被引:12
作者
Al-Tawfiq, Jaffar A. [1 ,2 ]
Omrani, Ali S. [3 ]
Memish, Ziad A. [4 ,5 ]
机构
[1] Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia
[2] Indiana Univ, Sch Med, Indianapolis, IN 46202 USA
[3] King Faisal Specialist Hosp & Res Ctr, Dept Med, Infect Dis Sect, Riyadh 11211, Saudi Arabia
[4] Minist Hlth, Riyadh 11514, Saudi Arabia
[5] Alfaisal Univ, Coll Med, Riyadh 11533, Saudi Arabia
关键词
coronavirus; MERS; Middle East respiratory syndrome; HEALTH-CARE WORKER; MERS-COV; SAUDI-ARABIA; FAMILY CLUSTER; INFECTION; PILGRIMS; TRANSMISSION; RIBAVIRIN; PREVALENCE; ANTIBODIES;
D O I
10.1007/s11684-016-0446-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.
引用
收藏
页码:111 / 119
页数:9
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