Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease

被引：41

作者：

Akagi, Masaaki ^{[1
]}

Matsui, Nobuaki ^{[1
]}

Akae, Haruka ^{[1
]}

Hirashima, Nana ^{[1
]}

Fukuishi, Nobuyuki ^{[1
]}

Fukuyama, Yoshiyasu ^{[1
]}

Akagi, Reiko ^{[2
]}

机构：

[1] Tukushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan

[2] Yasuda Womens Univ, Fac Pharm, Asaminami Ku, Hiroshima 7310153, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2015年 / 127卷 / 02期

关键词：

Nonpeptide neurotrophic agents; Natural products; Senescence-accelerated mice; Rat cortical neurons; NERVE GROWTH-FACTOR; ACETYLTRANSFERASE CHAT ACTIVITY; SENESCENCE-ACCELERATED MICE; NGF-POTENTIATING ACTIVITY; AMYLOID FIBRIL FORMATION; NEURITE OUTGROWTH; GAMMA-SECRETASE; A-BETA; HONOKIOL; MAGNOLOL;

D O I：

10.1016/j.jphs.2014.12.015

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Developed regions, including Japan, have become "aged societies," and the number of adults with senile dementias, such as Alzheimer's disease (AD). Parkinson's disease, and Huntington's disease, has also increased in such regions. Neurotrophins (NTs) may play a role in the treatment of AD because endogenous neurotrophic factors (NFs) prevent neuronal death. However, peptidyl compounds have been unable to cross the blood-brain barrier in clinical studies. Thus, small molecules, which can mimic the functions of NFs, might be promising alternatives for the treatment of neurodegenerative diseases. Natural products, such as or nutraceuticals or those used in traditional medicine, can potentially be used to develop new therapeutic agents against neurodegenerative diseases. In this review, we introduced the neurotrophic activities of polyphenols honokiol and magnolol, which are the main constituents of Magnolia obovata Thunb, and methanol extracts from Zingiber purpureum (BANGLE), which may have potential therapeutic applications in various neurodegenerative disorders. (C) 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：155 / 163

页数：9

共 99 条

[1]

Honokiol and magnolol selectively interact with GARAA receptor subtypes in vitro [J].

Ai, JL ;

Wang, XM ;

Nielsen, M .

PHARMACOLOGY, 2001, 63 (01) :34-41

[2]

In vitro Evidence that an Aqueous Extract of Centella asiatica Modulates α-Synuclein Aggregation Dynamics [J].

Berrocal, Ruben ;

Vasudevaraju, Padmaraju ;

Indi, Shantinath Satappa ;

Rao, Krothapalli Raja Surya Sambasiva ;

Rao, K. S. .

JOURNAL OF ALZHEIMERS DISEASE, 2014, 39 (02) :457-465

[3]

Conformational transition in the substrate binding domain of β-secretase exploited by NMA and its implication in inhibitor recognition: BACE1-myricetin a case study [J].

Chakraborty, Sandipan ;

Kumar, Sanjay ;

Basu, Soumalee .

NEUROCHEMISTRY INTERNATIONAL, 2011, 58 (08) :914-923

[4]

Aggregation properties of a short peptide that mediates amyloid fibril formation in model proteins unrelated to disease [J].

Chaudhary, Nitin ;

Singh, Shashi ;

Nagaraj, Ramakrshnan .

JOURNAL OF BIOSCIENCES, 2011, 36 (04) :679-689

[5]

Contents of polyphenols in fruit and vegetables [J].

Cieslik, E ;

Greda, A ;

Adamus, W .

FOOD CHEMISTRY, 2006, 94 (01) :135-142

[6]

9,10-Anthraquinone hinders β-aggregation: How does a small molecule interfere with Aβ-peptide amyloid fibrillation? [J].

Convertino, Marino ;

Pellarin, Riccardo ;

Catto, Marco ;

Carotti, Angelo ;

Caflisch, Amedeo .

PROTEIN SCIENCE, 2009, 18 (04) :792-800

[7]

The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease [J].

Counts, SE ;

Mufson, EJ .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2005, 64 (04) :263-272

[8]

Bioavailability of the Polyphenols: Status and Controversies [J].

D'Archivio, Massimo ;

Filesi, Carmelina ;

Vari, Rosaria ;

Scazzocchio, Beatrice ;

Masella, Roberta .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (04) :1321-1342

[9]

"Clicked" Sugar-Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations [J].

Dolai, Sukanta ;

Shi, Wei ;

Corbo, Christopher ;

Sun, Chong ;

Averick, Saadyah ;

Obeysekera, Dinali ;

Farid, Mina ;

Alonso, Alejandra ;

Banerjee, Probal ;

Raja, Krishnaswami .

ACS CHEMICAL NEUROSCIENCE, 2011, 2 (12) :694-699

[10]

Protective and Antioxidant Effects of a Chalconoid from Pulicaria incisa on Brain Astrocytes [J].

Elmann, Anat ;

Telerman, Alona ;

Erlank, Hilla ;

Mordechay, Sharon ;

Rindner, Miriam ;

Ofir, Rivka ;

Kashman, Yoel .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, 2013

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