E-I balance and human diseases - from molecules to networking

被引：143

作者：

Eichler, Sabrina A. ^{[1
]}

Meier, Jochen C. ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, RNA Editing & Hyperexcitabil Disorders Helmholtz, Berlin, Germany

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2008年 / 1卷

关键词：

inhibition; excitation; E-I balance; autism; mental retardation; epilepsy; schizophrenia; Alzheimer's disease;

D O I：

10.3389/neuro.02.002.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.

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