Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats

被引：42

作者：

Cagetti, E ^{[1
]}

Baicy, KJ ^{[1
]}

Olsen, RW ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 01期

关键词：

alcohol withdrawal; anxiety; chronic intermittent ethanol; hyperexcitability; kindling; pentylentetrazol; topiramate;

D O I：

10.1097/00001756-200401190-00040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Topiramate, a novel anticonvulsant drug, has CNS depressant activity including enhancement of GABAergic inhibitory synaptic transmission. Drugs of this pharmacological spectrum might have utility in assuaging drug addiction. This study analyzes the ability of TPM to reduce withdrawal signs in the kindling model of ethanol dependence: chronic intermittent ethanol (CIE) rats. After CIE, persistent withdrawal signs are shown by an increased seizure susceptibility to the convulsant drug pentylenetetrazol and increased anxiety measured on the elevated plus-maze. Topiramate increased significantly the PTZ seizure threshold in CIE but not in control rats. On the elevated plus-maze, Topiramate was markedly more effective in CIE rats than in controls. Topiramate may have a therapeutic efficacy in treating alcohol withdrawal symptoms.

引用

页码：207 / 210

页数：4

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