A new family of high-affinity ABC manganese and zinc permeases

被引：133

作者：

Claverys, JP ^{[1
]}

机构：

[1] Univ Toulouse 3, CNRS, Lab Microbiol & Genet Mol, UMR5100, F-31062 Toulouse, France

来源：

RESEARCH IN MICROBIOLOGY | 2001年 / 152卷 / 3-4期

基金：

美国国家卫生研究院;

关键词：

adhesion; competence; iron; LraI family; manganese; metal ion transport; photosynthesis; regulation; sporulation; virulence; zinc;

D O I：

10.1016/S0923-2508(01)01195-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Phylogenetic analysis of 47 extracellular putative metal binding receptors (MBRs) belonging to the newly defined cluster suggests the existence of two subclusters. The question of substrate specificity of the corresponding ATP binding cassette (ABC) permeases is discussed, based on data collected from 19 of them concerning their regulation, metal requirement of permease mutants, metal uptake and metal binding. The proposal that the two subclusters correspond to paralogous metal permeases dedicated primarily to manganese and to zinc transport is made. The question of a direct role of MBRs as adhesins of Gram-positive bacteria is then discussed and the importance of metal permeases for cellular processes and host-bacteria interactions is reviewed. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：231 / 243

页数：13

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