Channelopathies: Kir2.1 mutations jeopardize many cell functions

被引：42

作者：

Jongsma, HJ

Wilders, R

机构：

[1] Univ Utrecht, Med Ctr, Dept Med Physiol, NL-3508 AB Utrecht, Netherlands

[2] Univ Amsterdam, Dept Physiol, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 18期

关键词：

D O I：

10.1016/S0960-9822(01)00437-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Andersen's syndrome is caused by mutations in the potassium channel Kir2.1, a major determinant of resting membrane potential. The clinical features of this disease illustrate the importance of a stable resting membrane potential for many cell functions.

引用

页码：R747 / R750

页数：4

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