Studies on 1-O-acetylbritannilactone and its derivative, (2-O-butyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone ester

被引：37

作者：

Liu, SX

Liu, H

Yan, WY

Zhang, L

Bai, NS

Ho, CT ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

[2] Hebei Univ Sci & Technol, Shijiazhuang 050018, Peoples R China

[3] Xian Jiaotong Univ, Xian 710049, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 05期

关键词：

inula britannica; sesquiterpene lactone; cytotoxicity; (2-O-butyloxime-1-phenyl) propionic acid derivative; x-ray crystal structures;

D O I：

10.1016/j.bmcl.2003.12.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The crystal structures of 1-O-acetylbritannilactone 6 isolated from Inula britannica, and its derivative (2-O-butyloxime-3-phenyl) propionyl 1-O-acetylbritannilactone ester 7 are reported. The structure of synthesized derivative 7 was established by spectroscopic methods. Both compounds inhibited the growth of human HL-60, Bel-7402 cell lines and compound 7 had the stronger cytotoxic activity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1101 / 1104

页数：4

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