Early growth determines longevity in male rats and may be related to telomere shortening in the kidney

被引：238

作者：

Jennings, BJ ^{[1
]}

Ozanne, SE ^{[1
]}

Dorling, MW ^{[1
]}

Hales, CN ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QR, England

来源：

FEBS LETTERS | 1999年 / 448卷 / 01期

基金：

英国惠康基金;

关键词：

telomere; longevity; rat; low protein; kidney; growth;

D O I：

10.1016/S0014-5793(99)00336-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maternal protein undernutrition can influence the growth and longevity of male offspring in the rat, We tested the hypothesis that these differences in longevity were associated with changes in the rate of telomere shortening. We found age-related shortening of telomeres in the liver and kidney but not in the brain of male rats. Growth retardation in postnatal life was associated with significantly longer kidney telomeres and an increased longevity. Conversely, growth retardation during the foetal life followed by postnatal catch-up growth was associated with a shorter life span and shorter kidney telomeres, These findings may provide a mechanistic basis for epidemiological studies linking early growth retardation to adult degenerative diseases. (C) 1999 Federation of European Biochemical Societies.

引用

页码：4 / 8

页数：5

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