Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005

被引：62

作者：

Huang, Shih-Chen ^{[2
]}

Hsu, Yun-Wei ^{[3
]}

Wang, Hsuan-Chen ^{[3
]}

Huang, Sheng-Wen ^{[4
]}

Kiang, David

Tsai, Huey-Pin ^{[5
]}

Wang, Shih-Ming ^{[6
]}

Liu, Ching-Chuan ^{[6
]}

Lin, Kui-Hsiang ^{[7
]}

Su, Ih-Jen ^{[3
]}

Wang, Jen-Ren ^{[1
,2
,3
,5
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Med Lab Sci & Biotechnol, Tainan 701, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Inst Mol Med, Tainan 701, Taiwan

[3] Natl Hlth Res Inst, Div Clin Res, Tainan, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan, Taiwan

[5] Natl Cheng Kung Univ, Dept Pathol, Tainan 70101, Taiwan

[6] Natl Cheng Kung Univ, Coll Med, Dept Pediat, Tainan 70101, Taiwan

[7] Kaohsiung Med Univ, Dept Clin Lab, Kaohsiung, Taiwan

来源：

VIRUS RESEARCH | 2008年 / 131卷 / 02期

关键词：

enterovirus; 71; phylogenetic analysis; recombination;

D O I：

10.1016/j.virusres.2007.10.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genetic recombination is a well-known phenomenon for enteroviruses. In this study, we determined the phylogenetic relationships of five distinct regions of the EV71 genome for 73 EV71 isolates from 1986 and from 1998 to 2005 in Taiwan. Phylogenetic analyses showed that the 5'-UTR, VP4-VP2, VP1, and 3D regions of EV71 isolated in 2004 and 2005 were grouped into genotype C. However, the 2B region of these isolates differed in that it grouped with genotype B, indicating recombination within EV71 had occurred. This intratypic recombination was first seen in 2002 and became predominant in 2004 and 2005. The simplot and bootscan analyses identified two recombination points located at the 3'-termini of the 2A and 3C regions. This intratypic recombination was identified among naturally circulating EV71 isolates in Taiwan, therefore, it suggests that nonstructural genes may recombine to produce new EV71 variants. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：250 / 259

页数：10

共 46 条

[41] Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region [J].

Shimizu, H ;

Utama, A ;

Onnimala, N ;

Chen, L ;

Zhang, LB ;

Ma, YJ ;

Pongsuwanna, Y ;

Miyamura, T .

PEDIATRICS INTERNATIONAL, 2004, 46 (02) :231-235

[42] Frequency and dynamics of recombination within different species of human enteroviruses [J].

Simmonds, P ;

Welch, J .

JOURNAL OF VIROLOGY, 2006, 80 (01) :483-493

[43] A 2ND VIRUS-ENCODED PROTEINASE INVOLVED IN PROTEOLYTIC PROCESSING OF POLIOVIRUS POLYPROTEIN [J].

TOYODA, H ;

NICKLIN, MJH ;

MURRAY, MG ;

ANDERSON, CW ;

DUNN, JJ ;

STUDIER, FW ;

WIMMER, E .

CELL, 1986, 45 (05) :761-770

[44] Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release [J].

vanKuppeveld, FJM ;

Hoenderop, JGJ ;

Smeets, RLL ;

Willems, PHGM ;

Dijkman, HBPM ;

Galama, JMD ;

Melchers, WJG .

EMBO JOURNAL, 1997, 16 (12) :3519-3532

[45] Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000 [J].

Wang, JR ;

Tuan, YC ;

Tsai, HP ;

Yan, JJ ;

Liu, CC ;

Su, IJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (01) :10-15

[46] Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypes [J].

Yoke-Fun, Chan ;

AbuBakar, Sazaly .

BMC MICROBIOLOGY, 2006, 6 (1)

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