An aldol approach to the total synthesis of (+)-brefeldin A

被引：18

作者：

Wu, YK ^{[1
]}

Shen, X ^{[1
]}

Yang, YQ ^{[1
]}

Hu, Q ^{[1
]}

Huang, JH ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 01期

基金：

中国国家自然科学基金;

关键词：

cyclization; asymmetric aldolization; macrolides; lactones; natural products;

D O I：

10.1016/j.tetlet.2003.10.130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent selective route to (+)-brefeldin A (BFA) and 7-epi-BFA was developed, with the crucial C-4/C-5 stereogenic centers were established using Crimmins asymmetric aldolization. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：199 / 202

页数：4

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