Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: Solid-phase synthesis of ornithine analogues

被引:23
作者
Dankwardt, SM
Martin, RL
Chan, CS
Van Wart, HE
Walker, KAM
Delaet, NG
Robinson, LA
机构
[1] Roche Biosci, Inflammatory Dis Unit, Palo Alto, CA 94304 USA
[2] DuPont Pharmaceut Co, Res Labs, San Diego, CA 92121 USA
关键词
D O I
10.1016/S0960-894X(01)00384-5
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP). (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2085 / 2088
页数:4
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