Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis

被引：47

作者：

Alba Mane-Martinez, M. ^{[1
,2
]}

Olsson, Bob ^{[3
]}

Bau, Laura ^{[2
]}

Matas, Elisabet ^{[2
]}

Cobo-Calvo, Alvaro ^{[2
]}

Andreasson, Ulf ^{[3
]}

Blennow, Kaj ^{[3
]}

Romero-Pinel, Lucia ^{[2
]}

Martinez-Yelamos, Sergio ^{[2
]}

Zetterberg, Henrik ^{[3
,4
]}

机构：

[1] Univ Rovira & Virgili, Joan Univ Hosp 23, Tarragona, Spain

[2] Univ Barcelona, Bellvitge Univ Hosp, Barcelona, Spain

[3] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Molndal, Sweden

[4] UCL, Inst Neurol, London WC1E 6BT, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 299卷

关键词：

DIAGNOSTIC-CRITERIA; LESIONS; EXPRESSION; PROTEIN; NEURODEGENERATION; GUIDELINES; ASTROCYTES; CONVERSION; DISEASES;

D O I：

10.1016/j.jneuroim.2016.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, alpha-sAPP, beta-sAPP, and A beta 38, A beta 40, A beta 42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：112 / 117

页数：6

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