Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation

被引:31
作者
Knechtle, SJ [1 ]
Hamawy, MM [1 ]
Hu, HZ [1 ]
Fechner, JH [1 ]
Cho, CS [1 ]
机构
[1] Univ Wisconsin, Sch Med, Dept Surg, Madison, WI 53792 USA
关键词
D O I
10.1034/j.1600-065x.2001.1830116.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
Studies in non-human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non-human primates are T-cell depletion by and-CD3 immunotoxin and co-stimulation blockade. Each of these strategies has been extended into early human trials in renal transplantation. The results of these human and non-human primate studies are summarized. Continued progress in better and safer immunosuppressive methods remains closely linked to research using non-human primates. However, there has not been a one-to-one correspondence between efficacy in the primate and efficacy in humans. Rather, principles can be derived from non-human primate studies that can be extended into human trials with the knowledge that regimens will likely differ in humans compared to non-human primates.
引用
收藏
页码:205 / 213
页数:9
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