Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection

被引：22

作者：

Laurence, Jerome M. ^{[1
]}

Wang, Chuanmin ^{[1
,2
]}

Park, Euiyoun T. ^{[2
]}

Buchanan, Alexandra ^{[1
]}

Clouston, Andrew ^{[3
]}

Allen, Richard D. M. ^{[1
]}

Mccaughan, Geoffrey W. ^{[2
]}

Bishop, G. Alex ^{[1
,2
]}

Sharland, Alexandra F. ^{[1
]}

机构：

[1] Univ Sydney, Royal Prince Alfred Hosp, Collaborat Transplantat Res Grp, Bosch Inst, Sydney, NSW 2006, Australia

[2] Univ Sydney, Centenary Inst Canc Med & Cell Biol, AW Morrow Liver Immunobiol Lab, Sydney, NSW 2006, Australia

[3] Envoi Pathol, Brisbane, Qld, Australia

来源：

TRANSPLANTATION | 2008年 / 85卷 / 09期

关键词：

transplantation tolerance; indoleamine dioxygenase; 1-methyl tryptophan;

D O I：

10.1097/TP.0b013e31816fc27f

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a well-characterized rat model of liver transplantation, Piebald Virol Glaxo strain livers are accepted long term in fully mismatched Dark Agouti recipients (tolerance; TOL), but rejected in Lewis recipients (rejection; REJ). Spontaneous tolerance induction is associated with increased interferon-gamma expression, and we examined the role of the interferon-gamma-inducible immunomodulatory enzyme indoleamine dioxygenase (IDO) in this model. On day 3 after transplantation, IDO expression in the spleen of TOL recipients was significantly greater than in REJ. The B-cell population accounted for this early IDO increase. Intragraft expression of IDO increased to the same extent in both TOL and REJ. IDO inhibition for 7 days after transplantation red uced survival, but did not cause acute rejection of the liver in the TOL model. In conclusion, the differential IDO expression by B lymphocytes in the spleen of TOL recipients is not critical for preventing acute rejection.

引用

页码：1357 / 1361

页数：5

共 28 条

[1] Interferon-γ-modified dendritic cells suppress B cell function and ameliorate the development of experimental autoimmune myasthenia gravis [J].

Adikari, SB ;

Lian, H ;

Link, H ;

Huang, YM ;

Xiao, BG .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 138 (02) :230-236

[2] Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression [J].

Beutelspacher, SC ;

Pillai, R ;

Watson, MP ;

Tan, PH ;

Tsang, J ;

McClure, MO ;

George, AJT ;

Larkin, DFP .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2006, 36 (03) :690-700

[3]

Bishop GA, 1996, J IMMUNOL, V156, P4925

[4] A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation [J].

Braun, D ;

Longman, RS ;

Albert, ML .

BLOOD, 2005, 106 (07) :2375-2381

[5] INDUCTION OF IMMUNOLOGICAL TOLERANCE BY PORCINE LIVER ALLOGRAFTS [J].

CALNE, RY ;

SELLS, RA ;

PENA, JR ;

DAVIS, DR ;

MILLARD, PR ;

HERBERTSON, BM ;

BINNS, RM ;

DAVIES, DAL .

NATURE, 1969, 223 (5205) :472-+

[6] Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase [J].

Frumento, G ;

Rotondo, R ;

Tonetti, M ;

Damonte, G ;

Benatti, U ;

Ferrara, GB .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (04) :459-468

[7] CTLA-4-Ig regulates tryptophan catabolism in vivo [J].

Grohmann, U ;

Orabona, C ;

Fallarino, F ;

Vacca, C ;

Calcinaro, F ;

Falorni, A ;

Candeloro, P ;

Belladonna, ML ;

Bianchi, R ;

Fioretti, MC ;

Puccetti, P .

NATURE IMMUNOLOGY, 2002, 3 (11) :1097-1101

[8] A short course of cyclosporine immunosuppression inhibits rejection but not tolerance of rat liver allografts [J].

Huang, WH ;

Yan, YQ ;

De Boer, B ;

Bishop, GA ;

House, AK .

TRANSPLANTATION, 2003, 75 (03) :368-374

[9]

Konieczny BT, 1998, J IMMUNOL, V160, P2059

[10] Human placental indoleamine 2,3-dioxygenase: cellular localization and characterization of an enzyme preventing fetal rejection [J].

Kudo, Y ;

Boyd, CAR .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2000, 1500 (01) :119-124

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