Diversity and dialogue in immunity to helminths

被引：615

作者：

Allen, Judith E. ^{[1
]}

Maizels, Rick M. ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Immunol & Infect Res, Ashworth Labs, Edinburgh EH8 9YL, Midlothian, Scotland

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 06期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

REGULATORY T-CELLS; ALTERNATIVELY ACTIVATED MACROPHAGES; VACCINE-INDUCED IMMUNITY; INDUCED MITOGENIC FACTOR; SELECTIVE UP-REGULATION; SCHISTOSOMA-MANSONI; DENDRITIC CELLS; PROTECTIVE IMMUNITY; CUTTING EDGE; INTERFERON-GAMMA;

D O I：

10.1038/nri2992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.

引用

页码：375 / 388

页数：14

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