Direct-to-vial use of the AutoCyte PREP liquid-based preparation for cervical-vaginal specimens in three European laboratories

被引:57
作者
Vassilakos, P
Saurel, J
Rondez, R
机构
[1] Univ Hosp Geneva, Ctr Cytol & Clin Pathol, Geneva, Switzerland
[2] Univ Zurich, Inst Clin Pathol, CH-8006 Zurich, Switzerland
[3] Inst Histocytopathol, Bordeaux, France
关键词
cervical smears; cervix neoplasms; computer-assisted diagnosis; mass screening; AutoCyte PREP;
D O I
10.1159/000330870
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
OBJECTIVE: To compare the AutoCyte PREP direct-to-vial procedure to the conventional Pap smear in two large and similar patient groups compiled from the testing experience of three cytology laboratories in Switzerland and France. STUDY DESIGN: Randomly selected, large patient groups were evaluated using either the conventional Pap smear or the AutoCyte PREP direct-to-vial liquid-based preparation. Results were then compared statistically as to disease detection and sample adequacy. RESULTS: Specimen adequacy was greatly improved in the group tested with the AutoCyte PREP. PREP also demonstrated a significant reduction in ASCUS and ASCUS: LSIL + ratios. The three laboratories participating in this review found significantly improved detection of both low and high grade SIL. Routine use of AutoCyte PREP for cervical cytology screening offers substantial improvements in adequacy and disease detection.
引用
收藏
页码:65 / 68
页数:4
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