The role of c-jun N-terminal kinase (JNK) in Parkinson's disease

被引：78

作者：

Peng, J ^{[1
]}

Andersen, JK ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

IUBMB LIFE | 2003年 / 55卷 / 4-5期

关键词：

dopamine; MPTP; neuronal death; c-Jun amino-terminal kinases; Parkinson's disease;

D O I：

10.1080/1521654031000121666

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Given the critical role that the c-Jun N-terminal kinase (JNK) pathway plays in regulating many of the cellular processes which are affected in Parkinson's disease (PD), the possible importance of JNK in disease pathogenesis is being increasingly recognized. Here we review recent findings implicating the JNK signaling pathway in animal models of Parkinson's disease and discuss the relationship between this pathway and the prominent pathological processes observed in the disease state. We suggest that regulation of the JNK signaling pathway may be a central facet in potential treatments for the disease.

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收藏

页码：267 / 271

页数：5

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