Mixed-lineage kinase control of JNK and p38 MAPK pathways

被引：473

作者：

Gallo, KA ^{[1
]}

Johnson, GL

机构：

[1] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 09期

关键词：

D O I：

10.1038/nrm906

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.

引用

页码：663 / 672

页数：10

共 115 条

[1] Nuclear interpretation of Dpp signaling in Drosophila [J].

Affolter, M ;

Marty, T ;

Vigano, MA ;

Jazwinska, A .

EMBO JOURNAL, 2001, 20 (13) :3298-3305

[2]

AKBARZADEH S, IN PRESS J BIOL CHEM

[3] Ras and Rho GTPases: A family reunion [J].

Bar-Sagi, D ;

Hall, A .

CELL, 2000, 103 (02) :227-238

[4] Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation [J].

Behrens, A ;

Jochum, W ;

Sibilia, M ;

Wagner, EF .

ONCOGENE, 2000, 19 (22) :2657-2663

[5] Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo -: Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation [J].

Böck, BC ;

Vacratsis, PO ;

Qamirani, E ;

Gallo, KA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (19) :14231-14241

[6] Kinesin-dependent axonal transport is mediated by the Sunday driver (SYD) protein [J].

Bowman, AB ;

Kamal, A ;

Ritchings, BW ;

Philp, AV ;

McGrail, M ;

Gindhart, JG ;

Goldstein, LSB .

CELL, 2000, 103 (04) :583-594

[7] Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade [J].

Buchsbaum, RJ ;

Connolly, BA ;

Feig, LA .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (12) :4073-4085

[8] A CONSERVED BINDING MOTIF DEFINES NUMEROUS CANDIDATE TARGET PROTEINS FOR BOTH CDC42 AND RAC GTPASES [J].

BURBELO, PD ;

DRECHSEL, D ;

HALL, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (49) :29071-29074

[9] THE SMALL GTP-BINDING PROTEINS RAC1 AND CDC42 REGULATE THE ACTIVITY OF THE JNK/SAPK SIGNALING PATHWAY [J].

COSO, OA ;

CHIARIELLO, M ;

YU, JC ;

TERAMOTO, H ;

CRESPO, P ;

XU, NG ;

MIKI, T ;

GUTKIND, JS .

CELL, 1995, 81 (07) :1137-1146

[10] Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1 [J].

Cuenda, A ;

Dorow, DS .

BIOCHEMICAL JOURNAL, 1998, 333 :11-15

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