Mixed-lineage kinase control of JNK and p38 MAPK pathways

被引：473

作者：

Gallo, KA ^{[1
]}

Johnson, GL

机构：

[1] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 09期

关键词：

D O I：

10.1038/nrm906

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.

引用

页码：663 / 672

页数：10

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