A New Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell

被引：203

作者：

Cui, Lei ^{[1
]}

Zhong, Ye ^{[1
]}

Zhu, Weiping ^{[1
]}

Xu, Yufang ^{[1
]}

Du, Qingshan ^{[1
]}

Wang, Xin ^{[1
]}

Qian, Xuhong ^{[1
]}

Xiao, Yi ^{[2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

[2] Dalian Univ Technol DLUT, Dalian, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 05期

基金：

国家高技术研究发展计划(863计划);

关键词：

CANCER; XENOGRAFTS; ACTIVATION; MARKERS; DESIGN; AGENTS; EMISSION; THERAPY; CERVIX;

D O I：

10.1021/ol102975t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.

引用

页码：928 / 931

页数：4

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