A quality-effects model for meta-analysis

被引:206
作者
Doi, Suhail A. R. [1 ,3 ]
Thalib, Lukman [2 ]
机构
[1] Kuwait Univ, Dept Med, Safat 13110, Kuwait
[2] Kuwait Univ, Dept Community Med Biostat, Safat 13110, Kuwait
[3] Mubarak Al Kabeer Teaching Hosp, Div Endocrinol, Safat, Kuwait
关键词
D O I
10.1097/EDE.0b013e31815c24e7
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We introduce a quality-effects approach that combines evidence from a series of trials comparing 2 interventions. This approach incorporates the heterogeneity of effects in the analysis of the overall interventional efficacy. However, unlike the random-effects model based on observed between-trial heterogeneity, we suggest adjustment based on measured methodological heterogeneity between studies. We propose a simple noniterative procedure for computing the combined effect size under this model and suggest that this could represent a more convincing alternative to the random effects model.
引用
收藏
页码:94 / 100
页数:7
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