In vivo behavior of three different injectable hydraulic calcium phosphate cements

被引：314

作者：

Apelt, D

Theiss, F

El-Warrak, AO

Zlinszky, K

Bettschart-Wolfisberger, R

Bohner, M

Matter, S

Auer, JA

von Rechenberg, B

机构：

[1] Univ Zurich, Fac Vet Med, Equine Dept, MSRU, CH-8057 Zurich, Switzerland

[2] Univ Zurich, Fac Vet Med, Equine Hosp, CH-8057 Zurich, Switzerland

[3] Dr Robert Mathys Fdn, CH-2544 Bettlach, Switzerland

[4] Stratec Med, CH-4436 Oberdorf, Switzerland

来源：

BIOMATERIALS | 2004年 / 25卷 / 7-8期

关键词：

brushite; calcium phosphate cement; bioresorption; bone healing;

D O I：

10.1016/j.biomaterials.2003.08.073

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Two dicalcium phosphate dihydrate (DCPD) hydraulic cements and one apatite hydraulic cement were implanted in epiphyseal and metaphyseal, cylindrical bone defects of sheep. The in vivo study was performed to assess the biocompatibility of the DCPD cements, using the apatite cement as control. After time periods of 2, 4 and 6 months the cement samples were clinically and histologically evaluated. Histomorphometrically the amount of new bone formation, fibrous tissue and the area of remaining cement were measured over time. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. All cements were replaced by different amounts of new bone. The two DCPD-cements showed the highest new bone formation and least cement remnants at 6 months, whereas the apatite was almost unchanged over all time periods. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1439 / 1451

页数：13

共 58 条

[51]

Effect of biphasic calcium phosphate on human macrophage functions in vitro [J].